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Cancer Studies

The Cancer Network supports a wide range of clinical studies which are helping to progress cancer care in Scotland and beyond, and all Scottish research ongoing within the network is registered with the National Institute of Health Research (NIHR).

The cancer clinical trial portfolio is very dynamic and is frequently changing as studies open and close to recruitment. Across Scotland, there is a wide range of clinical trials happening in different disease sites. Information on trials happening in the UK can be found on the Be Part of Research platform and the Cancer Research UK website. For specific information on trials happening in Scotland please contact your cancer professional or your local cancer research network.

To highlight the clinical trials happening in Scotland the cancer research network will feature current trials happening during the different cancer awareness months that take place throughout the year.

 

JANUARY: CERVICAL CANCER AWARENESS MONTH

 

Cervical cancer is a cancer that develops in the lower part of the womb between the womb and the vagina. It can affect women of any age but tends to be more common in women between the ages of 30-45 years old.

Cervical screening is available for all women between 25-64 years and it is very important to take part as the test can show up any abnormal cells in the cervical area very early on.

Approximately 3,200 women are diagnosed with cervical cancer in the UK each year and it is the 13th most common cancer.

For more information please visit the Cancer Research UK website

 

 

Trial Spotlight

INTERLACE

Doctors often treat advanced cervical cancer, which cannot be removed with surgery, with radiotherapy in combination with a chemotherapy drug cisplatin. This is called chemoradiation treatment.

This phase 3 study is investigating whether it is more effective to have 2 new drugs called carboplatin and paclitaxel six weeks before the chemoradiation treatment and whether this makes the treatment more effective than having the standard treatment alone.

This study is recruiting patients in Glasgow.

Further information on this study is available here

 

COMICE

The usual treatment for cancer of the cervix is a combination of chemotherapy and radiotherapy. You have more chemotherapy if the cancer spreads elsewhere in the body or comes back, this is advanced cervical cancer.

In this trial, they are looking at olaparib and cediranib, both targeted drugs that work in different ways. Olaparib is a PARP inhibitor. It blocks an enzyme called PARP which helps damaged cells to repair themselves. Cediranib stops cancers from being able to make new blood vessels which they need to grow. 

Researchers think that having both drugs can shrink or stop the cancer growing. This may increase the time before the cancer starts to grow again after chemotherapy.

In this trial, some people have cediranib and olaparib and some have a placebo.

The aims of the trial are to see how well treatment works, learn more about the side effects and find out about quality of life 

This study is recruiting in Aberdeen, Edinburgh and Glasgow

Further information on the study can be found here

 

WO42017

The purpose of this clinical trial is to evaluate the effects, good or bad, of tiragolumab plus atezolizumab and atezolizumab alone in patients with metastatic and/or recurrent cervical cancer.

This study is recruiting in Glasgow.

More information on the study can be found here

 

innovaTV 205

This is an open label, multi-centre trial of tisotumab vedotin in combination with bevacizumab, pembrolizumab, or carboplatin in subjects with recurrent or stage IVB cervical cancer. The trial will be conducted in 2 parts: dose escalation followed by dose expansion

This study is currently recruiting in Glasgow.

More information on the study can be found here