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Cancer Studies

The Cancer Network supports a wide range of clinical studies which are helping to progress cancer care in Scotland and beyond, and all Scottish research ongoing within the network is registered with the National Institute of Health Research (NIHR).

The cancer clinical trial portfolio is very dynamic and is frequently changing as studies open and close to recruitment. Across Scotland, there is a wide range of clinical trials happening in different disease sites. Information on trials happening in the UK can be found on the Be Part of Research platform and the Cancer Research UK website. For specific information on trials happening in Scotland please contact your cancer professional or your local cancer research network.

To highlight the clinical trials happening in Scotland the cancer research network will feature current trials happening during the different cancer awareness months that take place throughout the year.

 

FEBRUARY: OESOPHAGEAL CANCER AWARENESS MONTH

 

Oesophageal cancer is a type of cancer affecting the oesophagus (gullet), the long tube that carries food from the throat to the stomach. Cancers in the upper and middle part of the oesophagus tend to be squamous cell carcinomas. These develop from cells that make up the inner lining of the oesophagus. Cancers in the lower part of the oesophagus tend to be a type called adenocarcinoma and start in gland cells.

Oesophageal cancer is more common in older people and more common in men than women.

It's the thirteenth most common cancer in the UK.

For more information on oesophageal cancer please visit the Cancer Research UK website

 

Trial Spotlight

OCCAMS

This study is using the latest technology to learn more about how cancer develops, as well as testing a new system to work out cancer stage for people with gastro oesophageal cancer. Researchers will look at changes in cells from people with a pre cancer or cancer and hope to be able to learn more about the causes of cancer to help them choose new treatments in future.

The study team have also developed a new way of working out how advanced the cancer stage is and think this will give doctors more information about the likely outcome (prognosis). It combines a new way of looking at how the cancer spreads using scans, alongside looking at changes in the DNA of cancer cells.

This trial is recruiting patients in Edinburgh, Dundee and Kilmarnock.

Further information on OCCAMS can be found here

 

SCOPE 2

SCOPE 2 is a randomised trial looking at a higher than normal dose of radiotherapy and a different type of chemotherapy to treat oesophageal cancer. 

SCOPE 2 is recruiting in Aberdeen, Glasgow, Dundee and Inverness.

More information on the trial can be found here

 

SPOTLIGHT

Spotlight is a Phase III study for adults with newly diagnosed, advanced or metastatic gastric or gastroesophageal junction (GEJ) cancer who have not had chemotherapy in the past 6 months and who have a HER2-negative tumor.

This study will test whether an investigational drug called Zolbetuximab is safe and effective when used together with mFOLFOX6 and will also study the overall survival rates of the patients and the types of side effects.

SPOTLIGHT is recruiting in Aberdeen and Dundee.

Further study information can be found here

 

ADD ASPIRIN

A study to assess whether regular aspirin use after standard therapy prevents recurrence and prolongs survival in patients with early stage common solid tumours, including oesophageal cancer.

Add aspirin is currently recruiting in many hospitals in Scotland.  

Further information can be found here

 

KEYNOTE 585

A trial of pembrolizumab and chemotherapy for stomach and gastro oesophageal junction cancer.

In this trial, doctors are looking at the drug pembrolizumab, a type of immunotherapy, which stimulates the body’s immune system to fight cancer cells. The main aim of this trial is to find out whether pembrolizumab helps people who are having treatment for the first time. 

This trial is currently recruiting in Dundee.

Further information can be found here